01 - Set air fryer to 400°F and preheat for 3-5 minutes while preparing ingredients.
02 - Whisk together 2 large eggs and 2 tbsp milk in a shallow bowl until fully combined.
03 - Combine panko breadcrumbs, Parmesan cheese, garlic powder, paprika, black pepper, and salt in a separate shallow bowl.
04 - Dip each tilapia fillet into the egg mixture, allowing excess to drip off, then press firmly into the breadcrumb mixture to coat thoroughly on all sides.
05 - Lightly spray the air fryer basket with cooking oil. Place breaded fillets in a single layer without overcrowding; cook in batches if necessary.
06 - Cook for 10-12 minutes, flipping fillets halfway through cooking time, until the crust is golden brown and fish flakes easily when tested with a fork.
07 - Transfer to serving plates and garnish with fresh chopped parsley and lemon wedges. Serve while hot and crispy.